when send DATA to a particular host...during top to down going we first of all add PORT number to message at Transport layer then we add IP of destination at network layer adn then we add MAC address at DATA link layer ...
when data is recieved by intermediate ROUTER...it will see the MAC address mainly ...
now during data transfer from router1 to router2..source MAC is of router 1 and destination router is router2..
SO when we send data.... router will change..
SOURCE MAC and DESTINATION MAC...