As first and last position is fixed , we can only manipulate the middle 6 positions
P __ __ __ __ __ __ R
We have 6 positions and 6 letters left ( E , C , U , L , I , A )
So, we have $^6P_6$ (as we have to select & then arrange) or 6! or 720 different ways to fill the middle 6 places
∴ 720 different words can be formed out of the letters of the word "PECULIAR" beginning with P and ending with R.