Not RE. A machine that accepts only one string has this interpretation:
1. Accepts one string
2. Rejects all other strings
It is part 2 that makes it not RE. Because in order to check if part 2 is satisfied, we will have to check all the possible strings to make sure there's no violation (and the no of strings is infinite) and thus even for the 'Yes' case we don't have a procedure which can halt in a finite amount of time. Hence this makes it not RE.