$D_1 = det\begin{pmatrix}a&b&c\\x&y&z\\p&q&r\end{pmatrix}$
$\qquad = a(yr-qz) -b(xr-pz)+c(xq-py)$
$\qquad =ayr-aqz-bxr+bpz+cxq-cpy$
$D_2 = det\begin{pmatrix}-x&a&-p\\y&-b&q\\z&-c&r\end{pmatrix}$
$\qquad = -x(-br+cq) -a(yr-qz)-p(-cy+bz)$
$\qquad =bxr-cxq-ayr+aqz+cpy-bpz = -D_1$
$∴\color{green}{ \text{Correct option is C)}}$ $\color{red}{D_1 = -D_2}$