Answer : $2^{10} - 3^{4}$
number of input combinations for which $F$ becomes True = Total Combinations - number of input combinations for which $F$ becomes False
Total Combinations = $2^{10}$
Number of input combinations for which $F$ becomes False(logic 0) :
To make $F$ false, all the inputs to the Final OR Gate must be False. Thus, Pair wise Possibilities :
$(x_1,x_2)$ = 1 Possibility (Both must be True to make the Output False)
$(x_3,x_4)$ = 3 Possibility (At least One must be False)
$(x_5,x_6)$ = 3 Possibility (At least One must be True)
$(x_7,x_8)$ = 3 Possibility (At least One must be False)
$(x_9,x_{10})$ = 3 Possibility (At least One must be False)
Thus, Number of input combinations for which $F$ becomes False(logic 0) : $1*3*3*3*3 = 3^4$
So, Final Desired Answer = $2^{10} - 3^{4}$