
For a normal $2:1$ MUX,
$\mathrm{F}=\mathrm{S}'\mathrm{I}_0+\mathrm{S}\mathrm{I}_1$.
But here enable is active-low.
That means the MUX works only when $\mathrm{E}=0$.
So, the working condition is represented by $\mathrm{E}'$.
Therefore, the output becomes:
$\mathrm{F}=\mathrm{E}'(\mathrm{S}'\mathrm{I}_0+\mathrm{S}\mathrm{I}_1)$.
When $\mathrm{E}=1$, $\mathrm{E}'=0$, so $\mathrm{F}=0$.
When $\mathrm{E}=0$, $\mathrm{E}'=1$, so the MUX works normally.
Answer: C